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Fluconazole: Drug Description

Fluconazole is an antibiotic commonly prescribed for the treatment of fungal and yeast infections. These infections may affect almost any part of the body, including the genitals, bladder, lungs, blood, brain, and mouth. The medication is most commonly used to treat infections caused by Candida fungus. Thus, you can use generic Fluconazole to treat the following:

  • Vaginal infection (vaginal candidiasis)
  • Thrush of the mouth
  • Urinary tract infections
  • Peritonitis
  • Esophageal fungal infection
  • Oropharyngeal candidiasis
  • Bloodstream infections (candidemia)
  • Pneumonia
  • Cryptococcal meningitis
  • Oropharyngeal candidiasis
  • Systemic Candida infections (disseminated candidiasis, pneumonia, etc.)
Fluconazole can be used for the treatment of fungal infections in children as young as six months old. The medication is also approved for the prevention of yeast infections in patients with suppressed immune system due to bone marrow transplantation or HIV/AIDS.

Off-label uses of the medicine include the treatment of other infections.

Mechanism of Action

Fluconazole contains the active component fluconazole, which belongs to a group of drugs known as azole antifungals. Fluconazole destroys the Candida fungi by stopping them from producing ergosterol, which is a substance necessary for the cell membrane of fungi. Fungi cannot survive without these membranes. That’s how fluconazole kills fungi and help treat infections.

How Supplied

Fluconazole comes in the form of tablet, oral suspension, and injection. There are four strengths of Fluconazole tablets: Fluconazole 50mg, Fluconazole 100mg, Fluconazole 150mg, and Fluconazole 200mg.

Proper Use

  • Fluconazole tablets should be swallowed whole with water, either on a full or empty stomach. You can take Fluconazole at any time.
  • Oral suspension should be shaken before taking. Measure the dose with a special spoon.
  • Do not discontinue Fluconazole before you finish the entire course of treatment even if your symptoms improve.
  • Do not change Fluconazole dosage unless it is your health care provided who have instructed you to do so. Remember that taking larger dose than prescribed will not increase the effectiveness of the drug.
  • Read the Patient Information Leaflet before starting the treatment. The leaflet provides information on how Fluconazole should be taken. It is important that you understand this information to ensure that the medication will not cause harm to your health.


You should take Fluconazole as prescribed by your health care provider. If using Fluconazole, you will find the recommended dosages for the treatment of different Candida infections in the Patient Information Leaflet.

The dosage of Fluconazole depends on the type of fungal infection being treated and on some other factors, such as your age and weight.

If you have vaginal candidiasis, you should use Fluconazole 150mg, because the recommended dosage for the treatment of this condition is 150mg taken as a single dose. Other infections should be treated with multiple doses:

  • The recommended Fluconazole dosage for the treatment of oropharyngeal candidiasis is 200mg on the first day of treatment, followed by 100mg taken once a day for 2 weeks. Although the symptoms of the infection may improve within several days, the treatment should be continued to reduce the risk of relapse. Consult your doctor if your symptoms do not improve within a week.
  • When treating esophageal candidiasis, the recommended starting dosage is 200mg on the first day of treatment, followed by 100mg taken once a day for 2-3 weeks. In some cases doses of up to 400mg a day may be used.
  • People with systemic Candida infections are commonly prescribed up to 400mg once daily.
  • When treating urinary tract infections and peritonitis, the recommended Fluconazole dosage ranges from 50mg to 200mg daily.
  • When using Fluconazole for cryptococcal meningitis, the recommended dosage is 400mg taken on the first day of treatment, followed by 200mg taken once a day for up to 12 weeks.
  • Fluconazole dosage of 400 mg once daily is common when preventing candidiasis in people undergoing bone marrow transplantation.
Your dose may be adjusted if you have liver or kidney disease, or some other severe conditions. The appropriate pediatric dosage of Fluconazole is based on the child's weight and age.

Fluconazole has shown to be an effective antibiotic that helps treat various fungal infections. It is a safe medication that was approved by the FDA in 1990.